{"title":"Metabolic Research","description":"\u003cp\u003eMetabolic Research brings together compounds studied in models of energy balance, nutrient sensing and lipid metabolism. It covers incretin and glucagon receptor agonists (Retatrutide, Tirzepatide), amylin analogues (Cagrilintide, Eloralintide), fixed-ratio research blends, a modified growth-hormone fragment (AOD-9604), an NNMT inhibitor (5-Amino-1MQ) and L-Carnitine.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eReceptor targets studied:\u003c\/strong\u003e GLP-1R, GIPR, GCGR, amylin and calcitonin receptors\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePathways studied:\u003c\/strong\u003e Incretin signalling, satiety signalling, lipolysis, NAD+ salvage and mitochondrial fatty-acid transport\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTypical models:\u003c\/strong\u003e Receptor-binding and cAMP assays, adipocyte cultures, hepatocyte and metabolic cell models\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cem\u003eAll products are supplied for in vitro laboratory research only. Not for human or veterinary use. No dosing or protocol guidance is provided.\u003c\/em\u003e\u003c\/p\u003e","products":[{"product_id":"lab-research-5amino-peptide","title":"5-Amino-1MQ 50mg","description":"\u003cp\u003e\u003cstrong\u003e5-Amino-1MQ\u003c\/strong\u003e is a research product containing 5-amino-1-methylquinolinium, a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). It is not a peptide. NNMT is an enzyme that consumes both nicotinamide and S-adenosylmethionine, and its activity is elevated in adipose tissue in several rodent models of metabolic dysfunction; 5-Amino-1MQ is the standard membrane-permeable tool compound for studying that pathway. The product information should be reviewed alongside appropriate research documentation and should not be presented as an approved medicine. \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompound:\u003c\/strong\u003e 5-Amino-1-methylquinolinium\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative identifier:\u003c\/strong\u003e 5-Amino-1MQ; CAS 42464-96-0\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eQuantity per vial:\u003c\/strong\u003e 50mg\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder, sealed vial\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClassification:\u003c\/strong\u003e Investigational small-molecule enzyme inhibitor\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMechanism studied:\u003c\/strong\u003e Selective NNMT inhibition\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch area:\u003c\/strong\u003e Adipocyte metabolism and NAD+ salvage pathway models\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eImportant:\u003c\/strong\u003e 5-Amino-1MQ is a preclinical research chemical and not an approved medicine. 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The product information should be reviewed alongside appropriate research documentation and should not be presented as an approved medicine.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompound:\u003c\/strong\u003e Cagrilintide\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlternative identifier:\u003c\/strong\u003e NN9838; AM833; CAS 1415456-99-3\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eQuantity per vial:\u003c\/strong\u003e 10mg\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder, sealed vial\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClassification:\u003c\/strong\u003e Investigational amylin analogue\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReceptor activity:\u003c\/strong\u003e Amylin and calcitonin receptor agonist\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eResearch area:\u003c\/strong\u003e Amylin-receptor pharmacology; rodent energy-balance models\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eImportant:\u003c\/strong\u003e Cagrilintide is in clinical development and is not an approved medicine. 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